Given civilization's diverse and often divisive responses to the past several years of a pandemic, Legionella outbreaks, and climate changes with consequence, the global collective of building professionals would benefit from a retooling starting with a deeper understanding of the implied meanings of indoor environmental quality (IEQ) and heating, ventilation and air conditioning (HVAC). Additionally, it would benefit from newer and modernized systems to facilitate compliance with evolving IEQ standards and mitigate the indoor environmental challenges brought to public awareness through circumstances affecting all citizens. From a practitioner's perspective, this paper presents an application-based explanation for key terms and identifies potential operational conflicts between ASHRAE Standards 62.1, 62.2, 241 and Standard 55 created due to inadequate understanding of these terms within industry and society. It addresses IEQ/HVAC operational incompatibilities found within single-purpose systems. It introduces one potential solution illustrating hydronic-based hybrid HVAC systems with domestic water heat-interface units to enable healthier indoor environments, specifically for the quality of air, thermal comfort and potable hot water.