Programa del congreso
Resúmenes y datos de las sesiones para este congreso. Seleccione una fecha o ubicación para mostrar solo las sesiones en ese día o ubicación. Seleccione una sola sesión para obtener una vista detallada (con resúmenes y descargas, si están disponibles).
|
Resumen diario |
| Sesión | |
|
Mi-S2.4-SE:Nano: Sesión Especial: Nanomedicina: Nanotecnología al servicio de la salud Lugar: Aula 1.05 Presidente de la sesión: Aranzazu Villasante Presidente de la sesión: Jesús Martínez de la Fuente | |
    | |
15:15 - 15:30
Remote Magneto–Thermal Modulation of Reactive Oxygen Species Balance Enhances Tissue Regeneration In Vivo 1: Instituto de Nanociencia y Materiales de Aragón, Spain; 2: Istituto di Scienze Applicatee Sistemi Intelligenti “E.Caianiello” Consiglio Nazionale delle Ricerche, Italy; 3: Institute of Biotechnology College of Natural Sciences, University of Rzeszow, Poland; 4: Centro de Investigación Biomédica en Red de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN) One of the hallmarks of tissue repair is the production of reactive oxygen species (ROS), which modulate processes such as cell proliferation. Although several attempts have been made to manipulate ROS levels to increase tissue repair, the lack of techniques able to remotely manipulate the redox homeostasis has hindered its progress. Herein, we present a new approach for tuning the ROS levels using magnetic nanoparticles (MNPs) that act as nanoheaters when exposed to an alternating magnetic field. We designed two MnxFe3-xO4 MNPs (with a low and a high Mn2+content) and probed the possibility to modulate the ROS balance by magneto-thermal stimulation in the invertebrate model organism Hydra vulgaris, able to fully regenerate. We found a biphasic modulation of the ROS levels played by the MNPs, while MNPs with the lower Mn2+ content are able to positively modulate the regeneration potential under magnetostimulation, MNPs with the higher Mn2+ content cause a different redox imbalance, negatively affecting the regeneration dynamic. This innovative approach reveals a new way for manipulating redox homeostasis that could advance in the field of tissue engineering.
| |