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Vi-P3: Sesión de pósteres III Lugar: Zona pósteres | |
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Low-nitrogen open-source setup for chronic normobaric hypoxia in rodent models 1: Unit of Biophysics and Bioengineering, Faculty of Medicine, University of Barcelona, Barcelona, Spain; 2: CIBER of Respiratory Diseases (CIBERES), Madrid, Spain; 3: Faculdade de Engenharias e Tecnologias, Universidade Save. Maxixe, Inhambane, Mozambique; 4: Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; 5: CIBER of Rare Diseases (CIBERER), Madrid, Spain Hypoxia plays a relevant pathophysiological role in human health and is a subject of intense investigation. In most cases, the source of N₂ required for the most conventional setting to continuously subject animals to hypoxia cannot be based on conventional bottles of compressed gas because of the high consumption required. A possible option would be an N₂ generator (based on N₂ extraction from room air by a pressure swing adsorption concentrator). However, these devices are expensive, limiting their use for this application. Such requirements for a continuous N₂ source limit the widespread extension of hypoxia-related in vivo research. In the present work, we aimed to design, build, and test an open-source, low-cost device requiring minimal N₂ provision. | |