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Vi-S6.2-ModGD: Modelado cardiovascular y gemelos digitales Lugar: Aula 0.01 Presidente de la sesión: Esther Pueyo Presidente de la sesión: José María Ferrero de Loma-Osorio | |
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9:30 - 9:45
Cardiac Digital Twins of Human Ventricular Electrophysiology using 12-Lead ECG and MRI 1: Universitat Pompeu Fabra, España; 2: University of Oxford, UK A cardiac digital twin is a virtual tool representing a patient’s heart that can simulate new events, such as evaluating therapies to inform clinical decision-making. We present a sex-specific digital twinning framework for personalising electrophysiological function based on routinely acquired magnetic resonance imaging data and the standard 12-lead electrocardiogram (ECG), while preserving known sex-related differences at the ionic level in the resulting digital twins. We demonstrate our digital twinning framework in three subjects, two female and one male, where our inferred reaction-Eikonal models reproduced the patient’s ECG with a Pearson’s correlation coefficient of 0.9 on average. The framework can be downloaded from GitHub. | |