Programa del congreso
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Resumen diario |
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Mi-S3.4-SE:Bmat: Sesión Especial: Biomateriales y terapias avanzadas Lugar: Aula 1.05 Presidente de la sesión: Ángel Raya | |
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16:30 - 16:45
Innovative hydrogel-based tissue engineering for miniaturized cancer-on-a-chip and bioprinted cancer models 1: Instituto de Investigación en Ingeniería de Aragón, Universidad de Zaragoza, España; 2: Instituto de Nanociencia y Materiales de Aragón, CSIC y Universidad de Zaragoza, España; 3: Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, España; 4: Division of Biomaterials & Tissue Engineering, UCL Eastman Dental Institute, University College London, Reino Unido Cutting-edge tissue engineering applications such as the promising cancer models need innovative materials to produce hydrogels. Chicken egg white (EW) is an underexplored protein-based biomaterial, which mixed with the biopolymer gelatin are being widely researched for food technology applications. Interestingly, hydrogels of EW and gelatin have not been explored for tissue engineering applications like cancer models. Cancer-on-a-chip and bioprinted cancer models are at the technological forefront of tissue-engineered cancer models. However, the current used hydrogels for these models hinder their progress. Our work investigated hydrogels of EW and gelatin for cancer-on-a-chip and bioprinted cancer models. Our results show the enormous potential of using these hydrogels. Compared with other hydrogels used in cancer models, EW/gelatin hydrogels are easily available, cost-effective, have no ethical issues, their fabrication is straightforward, are highly biocompatible due to presence of molecular cues found in the extracellular matrix of tissues, and offer reproducibility of results, mechanical integrity, and effective growth of multi-cellular tumour structures. Our results also showcase the importance of the tumour microenvironment in tumour cell behaviour.
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