Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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CP5.1: Immunology 1 - 10 min talks Location: Lecture Theatre 2 Session Chair: Danielle Stanisic, Institute for Biomedicine and Glycomics, Griffith University Session Chair: Hannah Siddle, The University of Queensland | |
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Identifying Novel Non-CSP Antigen targets on the Surface of Malaria Plasmodium Falciparum Sporozoites 1: UNSW, Australia; 2: ANU, Australia Human infection with malaria begins with the injection of sporozoites by a feeding mosquito. The sporozoite surface has a dense layer of one, immunodominant protein, called circumsporozoite protein (CSP). This protein contains 38 NANP amino acid tandem repeats which are highly immunogenic. The current licensed malaria vaccines being rolled out in Africa (RTS,S and R21) both target CSP, however they require multiple boosters to maintain high antibody titre, with vaccine efficacy waning overtime. Given CSP’s immunodominance and prevalence, could it be acting as an immunological decoy, evolved to evade an immune response from other critical cell surface proteins on the parasite? Here, we have used a CSP-tolerant mouse model, immunising mice with human infective Plasmodium falciparum sporozoites to induce an immune response towards non-CSP antigens on the surface of the sporozoite. We then performed 10x single-cell sequencing of the expanded B cell clones from immunized mice and generated a panel of monoclonal antibodies. Using these monoclonals alongside, polyclonal sera we have identified non-CSP sporozoite surface antigens as potential targets for next generation malaria vaccines. | |