Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
|
Daily Overview |
| Session | |
|
CP15.1: Drugs & Drug Resistance 2 - 5 min talks sponsored by Institute for Biomedicine and Glycomics, Griffith University Location: Lecture Theatre 1 Session Chair: Jacinta Macdonald, Griffith University Session Chair: Rohith Kutty, Griffith University | |
    | |
Discovery and Validation of Novel Drug Targets for Sustainable Blowfly Control and Improved Sheep Welfare Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Science, The University of Melbourne The Australian sheep blowfly, Lucilia cuprina, is the principal cause of flystrike (cutaneous myiasis) in sheep, incurring losses of ~AU$320 million annually and inflicting severe welfare impacts in sheep. Current treatment includes insecticides and surgical mulesing; however, heavy reliance on insecticides has accelerated resistance, while mulesing draws strong public opposition due to animal welfare concerns—undermining both ethics and economic outcomes. Sustainable alternatives will be explored through the discovery and validation of novel blowfly-specific molecular targets identified using population genetic data from blowfly populations across Australia. RNA interference (RNAi) will be used to silence top molecular targets and protein modelling, and larval bioassays will be used for identifying and testing top candidate compounds. This project is expected to provide validated targets and candidate compounds for L. cuprina as the basis for novel larvicides to overcome existing insecticide resistance and reduce dependence on mulesing. | |