Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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CP9.1: Vaccines 10 min talks sponsored by Institute for Biomedicine and Glycomics, Griffith University Location: Lecture Theatre 2 Session Chair: Danielle Stanisic, Institute for Biomedicine and Glycomics, Griffith University Session Chair: Anouschka Akerman, The University of Queensland | |
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Rational discovery of a novel human hookworm subunit vaccine James Cook University, Australia Human hookworm infection, primarily caused by Necator americanus, remains a major global health burden, with vaccine development limited by insufficient identification of protective antigens. This study utilised a proteome microarray of recombinant secreted proteins from adult N. americanus, screened with sera from individuals vaccinated with irradiated third-stage larvae (iL3), to identify immunodominant targets. Selected antigens were characterised and their orthologs identified in the rodent hookworm Nippostrongylus brasiliensis. Recombinant orthologs were evaluated in a mouse challenge model. One antigen, NBR17057 (ortholog of Na_11335), conferred significant protection, reducing intestinal worm burden and faecal egg output (p < 0.05) and inducing strong antigen-specific IgG responses. These findings support Na_11335 as a promising subunit vaccine candidate targeting the infective larval stage. Additional L3-stage antigens are being investigated to discover an effective novel human vaccine. | |