Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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CP9.1: Vaccines 10 min talks sponsored by Institute for Biomedicine and Glycomics, Griffith University Location: Lecture Theatre 2 Session Chair: Danielle Stanisic, Institute for Biomedicine and Glycomics, Griffith University Session Chair: Anouschka Akerman, The University of Queensland | |
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Title: A population genetics view of a multi-stage malaria vaccine candidate University of Melbourne, Australia Multi-stage, multi-antigen vaccination against malaria is a favoured strategy to improve on the modest efficacy offered by existing vaccines. However, current multi-stage vaccine design neglects the extensive antigenic diversity which exists within populations of Plasmodium falciparum circulating in endemic areas, which has contributed to the low efficacy of multiple single-stage candidates. Using parasite genomes from the MalariaGEN Pf8 release, we combined population genetics with immunoinformatics to assess the potential for vaccine escape of the pre-erythrocytic and blood-stage targets CSP and RH5. We found that the proportion of parasites in sub-Saharan Africa encoding both vaccine-matched alleles for these targets was very low. When we predicted the effects of observed amino acid substitutions on antibody and HLA binding, we found no impact on the RH5 component of the vaccine. However, the majority of parasites sampled had the potential to escape both anti-CSP C-terminal antibodies and vaccine-induced CD4+ T-cell memory responses. We conclude that CSP-based vaccines as components of multi-stage vaccines may not provide the advantage of increased efficacy due to pre-existing polymorphisms in the C-terminal of CSP. | |