Research data holds an integral part of scientific progress and discovery and has fueled data-driven approaches to applied research towards fast and high-impact outcomes. However, for data to be useful in such a way, it should be findable, accessible and stored in reusable format. Various initiatives to curb global information accessibility challenges have led to the creation of databases for collaborative research, monitoring and evaluation of progress and outputs, particularly in food systems. The aspects of production, market intelligence and food security remain with large data gaps, especially in Sub-Saharan Africa. It has been established that various crops that are indigenous to Sub-Saharan Africa present a great opportunity to boost food availability and nutritional diversity in local agriculture despite climate change; however, information and/or data gaps about their farm-to-fork activities and challenges remain, while they are underutilized, unsubsidized and unmarketed. This work is part of a larger project that intends to establish facts on the utilisation of indigenous and neglected crops and build the foundations for promoting their reintegration in the food value chains across the southern African region. It aims to develop a farm-to-fork information system (FIS) to collect, store and share research data, findings and other relevant information pertaining to indigenous and neglected crops from farm to fork. The FIS is based on a relational database to be flexibly searchable and interactive dashboards for ease of data visualization Data pertaining to the agroecology, production, processing and value addition, storage, distribution, market access, nutritional value, household utilization as well as relevant policies and governance will be at the core of the FIS. Local and international partnerships will be leveraged to extend its potential impact. The FIS for the indigenous and neglected crops conceptualised and developed in this project is a novelty in the literature and practice.