Reactions of the mycotoxin citrinin under food processing conditions

Lea Brückner, Katharina Hadenfeldt, Lina Schürmann, Benedikt Cramer, Hans-Ulrich Humpf

University of Muenster, Germany

Microbial zearalenone transformation through phosphorylation does not mitigate its toxicity

Ivan Pavlov¹, Muhammad Asaduzzaman¹, Ting Zhou², Imourana Alassane-Kpembi¹

¹University of Montreal; ²Guelph Research and Development Centre, Agriculture and Agri-Food Canada

Insights into mycotoxin fate during digestion: the effect of individual and combination exposures

Carolina Sousa Monteiro¹, Eugénia Pinto^2,3, Miguel A. Faria¹, Sara C. Cunha¹

¹LAQV-REQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Portugal; ²Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, Porto, Portugal; ³Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal

Enzymatic detoxification of fumonisins in bioethanol production: a promising mitigation strategy for safer DDGS

Julian Witt, Nicolas Hardt, Stefan Helmer, Christian Leggewie

Biomin Phytogenics GmbH, dsm-firmenich R&D Center Dortmund, Germany

Detoxification of deoxynivalenol by glutathione transferases

Herbert Michlmayr^1,2, Martin Siller^1,3, Lidija Kenjeric^4,5, Gerlinde Wiesenberger¹, Maria Doppler^5,6, Alexandra Malachova^4,5, Manuel Hofer⁷, Wolfgang Schweiger^3,7, Barbara Steiner⁷, Karl G. Kugler⁸, Klaus F. X. Mayer⁸, Hermann Buerstmayr⁷, Rainer Schuhmacher⁵, Rudolf Krska^5,9, Nikolaos E. Labrou¹⁰, Anastassios C. Papageorgiou², Gerhard Adam¹

¹University of Natural Resources and Life Sciences Vienna (BOKU), Department of Applied Genetics and Cell Biology, Institute of Microbial Genetics (IMiG), Tulln, Austria; ²Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; ³dsm-firmenich ANH Research Center Tulln, TFZ Tulln, Technopark 1, 3430 Tulln, Austria; ⁴FFoQSI GmbH – Austrian Competence Centre for Feed and Food Quality, Safety and Innovation, Tulln, Austria; ⁵University of Natural Resources and Life Sciences Vienna (BOKU), Department of Agrobiotechnology, IFA-Tulln, Institute of Bioanalytics and Agro-Metabolomics, Tulln, Austria; ⁶University of Natural Resources and Life Sciences Vienna (BOKU), Core Facility Bioactive Molecules: Screening & Analysis, Tulln, Austria; ⁷University of Natural Resources and Life Sciences Vienna (BOKU), Department of Agrobiotechnology, IFA-Tulln, Institute of Biotechnology in Plant Production, Tulln, Austria; ⁸Plant Genome and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany; ⁹Institute for Global Food Security, School of Biological Sciences, Queen’s University Belfast, Belfast, Northern Ireland; ¹⁰Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece

Aflatoxins contamination in tiger nuts: implications for food safety and regulation

Marta Sopel, Alwin Kruijt, Josipa Grzetic Martens

Wageningen Food Safety Research

Multi-mycotoxin determination in meat alternatives: occurrence, dietary exposure, risk characterization, and potential burden of disease

Octavian Augustin Mihalache¹, Raquel Torrijos^1,2, Chiara Dall'Asta¹

¹Department of Food and Drug, University of Parma, Parco Area delle Scienze 17/A, 43124, Parma, Italy; ²Department of Food Science and Toxicology, Faculty of Pharmacy, University of Valencia, Ave. Vicent Andrés Estellés s/n, 46100, Burjassot, Spain

Uptake of beauvericin, deoxynivalenol, zearalenone and other mycotoxins by black soldier fly larvae growing on contaminated maize

Marcus Trentzsch¹, Kipkoech Carolyne¹, Jakob Kühn¹, Christoph Gottschalk¹, Julia Jaster-Keller¹, John M. Wesonga², Ronald Maul³, Christoph Hutzler¹, Stefan Weigel¹

¹German Federal Institute for Risk Assessment (BfR), Department for Safety in the Food Chain, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany; ²Jomo Kenyatta University of Agriculture and Technology, Department of Horticulture and Food Security, P.O. Box 62000, 00200 Nairobi, Kenya; ³Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Department of Safety and Quality of Milk and Fish Products, Hermann-Weigmann-Straße 1, 24103 Kiel, Germany

Phosphorylation of deoxynivalenol and zearalenone in insects

Gerhard Adam¹, Maria Doppler^2,3, Herbert Michlmayr¹, Gerlinde Wiesenberger¹, Christoph Bueschl², Tamara Krska¹, Rainer Schuhmacher², Christian Hametner⁴, Franz Berthiller², Rudolf Krska²

¹Institute of Microbial Genetics, Department of Applied Genetics and Cell Biology, University of Natural Ressources and Life Sciences, Vienna (BOKU), Tulln, Austria; ²Institute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology (IFA Tulln), University of Natural Ressources and Life Sciences, Vienna (BOKU), Tulln, Austria; ³Core Facility Bioactive Molecules: Screening & Analysis, University of Natural Resources and Life Sciences, Vienna (BOKU), Tulln, Austria; ⁴Institute of Applied Synthetic Chemistry, Technische Universität Wien, Vienna, Austria

Fighting mycotoxin contaminations by studying the compositional and metabolomic dynamics of a Meta-Fusarium exposed to abiotic and biotic stress

Valentin Fiévet, Laetitia Pinson-Gadais, Stéphane Bernillon, Louis Carles, Florence Richard-Forget

INRAE (UR1264 Mycsa), France

Chemically diversified metabolite profiles in Penicillium roqueforti populations associated with ecological niche specialisation and domestication

Ewen Crequer¹, Emmanuel Coton¹, Gwennina Cueff¹, Johan V Christiansen³, Jens C Frisvad³, Ricardo Rodriguez De La Vega², Tatiana Giraud², Jean-Luc Jany¹, Monika Coton¹

¹Univ. Brest INRAE, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, F-29280 Plouzané, France; ²Université Paris-Saclay, CNRS, AgroParisTech, Laboratoire Ecologie Systématique et Evolution, UMR 8079, France; ³Department of Biotechnology and Biomedecine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark

Expansion of the multi-locus gene alignment approach to improve identification of the fungal species Alternaria alternata

Adetoye Adeyemo, Markus Schmidt-Heydt

Max Rubner-Institute, Germany

Genetic variability of the pathogenic Fusarium proliferatum from different hosts leads to significant differences in fumonisin production

Alessandra Villani¹, Antonia Susca¹, Stefania Somma¹, Mario Masiello¹, Marthe De Boevre², Sarah De Saeger², Hye-Seon Kim³, Stephen Harding³, Robert H. Proctor³, Antonio Moretti¹

¹Institute of Sciences of Food Production, Italy; ²Center of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium; ³USDA-ARS, NCAUR, Mycotoxin Prevention and Applied Microbiology Research Unit, Peoria, IL, USA

Volatile organic compounds: effective biomarkers and biocontrol tools against mycotoxins?

Laurie Josselin¹, Alessandra Villani², Salvatore Cervellieri², Thomas Netti², Daria Carella², Caroline De Clerck³, Robert H. Proctor⁴, Antonia Susca², Vincenzo Lippolis², Marie-Laure Fauconnier¹, Antonio Moretti²

¹Laboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium; ²Institute of Sciences of Food Production, National Research Council, Bari, Italy; ³AgricultureIsLife, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium; ⁴Mycotoxin Prevention and Applied Microbiology Unit, United States Department of Agriculture (USDA), National Center for Agricultural Utilization Research, Peoria, IL, USA

Interactions among strains of black aspergilli and ochratoxin A reduction

Júlia Marquès, M. Rosa Bragulat, F. Javier Cabañes, Gemma Castellá

Universitat Autònoma de Barcelona, Spain

4D model for intestinal toxicity profiling: a case study on Fusarium mycotoxins fumonisin B1 and deoxynivalenol

Janice Bergen¹, Claudia Iriarte-Mesa², Maximilian Jobst¹, Francesco Crudo¹, Doris Marko¹, Freddy Kleitz², Franz Berthiller³, Giorgia Del Favero¹

¹University of Vienna - Faculty of Chemistry, Department of Food Chemistry and Toxicology, Vienna, Austria; ²University of Vienna - Faculty of Chemistry, Department of Functional Materials and Catalysis, Vienna, Austria; ³Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, Vienna (BOKU), Austria

Identification of cellular targets of ochratoxin A utilizing a chemoproteomic approach

Johannes Borchers¹, Leonie Lutz¹, Stephanie Lamer², Andreas Schlosser², Angela Mally¹

¹University of Würzburg, Department of Toxicology, Würzburg, Germany; ²University of Würzburg, Rudolf Virchow Center, Würzburg, Germany

The presence and impact of phytoestrogens and zearalenone on the health of piglets

Dino Grgic^1,2, Barbara Novak³, Elisabeth Varga⁴, Dian Schatzmayyr³, Barbara Doupovec³, Doris Marko¹

¹Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria; ²Doctoral School in Chemistry, University of Vienna, Vienna, Austria; ³dsm-firmenich, Animal Nutrition & Health R&D Center, Tulln an der Donau, Austria; ⁴Unit Food Hygiene and Technology, Centre for Food Science and Veterinary Public Health, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine, Vienna, Vienna, Austria

Mechanisms underlying the combined effects of the mycotoxins deoxynivalenol and enniatin B in a liver cell model

Denis Habauzit, Sylvie Huet, Kevin Hogeveen, Valérie Fessard, Thibaut Léger

ANSES (French Agency for Food, Environmental and Occupational Health & Safety), France

The potential contribution of multiple mycotoxin exposure to esophageal cancer risk: insights from a case-control study in the Arsi-Bale districts, Ethiopia

Roger Pero-Gascon^1,2, Girma Mulisa^3,4, Tamrat Abebe³, Valerie McCormack⁵, Fazlur Rahman Talukdar^5,6, Marthe De Boevre¹, Sarah De Saeger^1,7

¹Ghent University, Belgium; ²Flanders Research Foundation, Belgium; ³Addis Ababa University, Ethiopia; ⁴Adama Hospital Medical College, Ethiopia; ⁵International Agency for Research on Cancer, France; ⁶University of Cambridge, UK; ⁷University of Johannesburg, South Africa

Immunosuppressive and antiestrogenic effects of Alternaria mycotoxins: alterperylenol and altertoxin I as novel emerging health concerns

Francesco Crudo¹, Vanessa Partsch^1,2, Dennis Braga¹, Giorgia Del Favero¹, Elisabeth Varga^1,3, Doris Marko¹

¹Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria; ²Doctoral School in Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria; ³Unit Food Hygiene and Technology, Centre for Food Science and Veterinary Public Health, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine, Vienna, Austria

Accelerating quantification of fungal analytes with fast polarity switching and scheduled MRM - is it on the cost of method performance?

Lidija Kenjeric^1,2, Alexandra Malachova¹, Rudolf Krska^2,3, Michael Sulyok²

¹FFoQSI GmbH, FFoQSI Austrian Competence Centre for Feed & Food Quality, Safety and Innovation, Tulln, Austria; ²University of Natural Resources and Life Sciences Vienna (BOKU), Department of Agrobiotechnology (IFA-Tulln), Institute of Bioanalytics and Agro-Metabolomics, Konrad-Lorenz-Straße 20, 3430 Tulln an der Donau, Austria; ³Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road, Belfast, BT7 1NN, Northern Ireland, United Kingdom

Patulin adducts and antibodies for immunoanalysis

Josep Vicent Mercader¹, Hadyn Duncan¹, Ismael Navarro-Fuertes², Consuelo Agullo², Antonio Abad-Somovilla², Antonio Abad-Fuentes¹

¹Spanish Council for Scientific Research, Spain; ²University of Valencia

Progressing towards rapid multiplex detection: a fluorescence immunoassay for ergot alkaloids, trichothecenes, and Fusarium toxins

Peter Carl^1,2, Timm Schwaar^1,2, Nick Gundermann^1,2, Rudolf J. Schneider², Matthias Koch², Daniel López-Puertollano³, Josep V. Mercader³

¹SAFIA Technologies GmbH, Germany; ²Federal Institute for Materials Research and Testing (BAM), Berlin, Germany; ³Spanish Council for Scientific Research, Institute of Agrochemistry and Food Technology, Valencia, Spain

Untargeted and rapid approaches for screening of deoxynivalenol in wheat bran

Vincenzo Lippolis¹, Leonardo Ciaccheri², Salvatore Cervellieri¹, Antonio Moretti¹, Anna Grazia Mignani², Annalisa De Girolamo¹

¹Institute of Sciences of Food Production (ISPA), National Research Council of Italy (CNR), Italy; ²Institute of Applied Physics “Nello Carrara” (IFAC), National Research Council of Italy (CNR), Italy

Mycotoxins in plant-based diets in Belgium

Maria Agustina Pavicich¹, Moustapha Soungalo Drabo², Lief Roose¹, Abdi Mohamed³, Celine Meerpoel¹, Katleen Raes², Sarah De Saeger¹

¹Centre of Excellence in Mycotoxicology and Public Health, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; ²Research Unit VEG-i-TEC, Faculty of Bioscience Engineering, Ghent University, Kortrijk, B-8500, Belgium; ³School of Plant Sciences, Haramaya University, P.O. Box 138, Dire Dawa, Ethiopia

Urinary multi-mycotoxin biomonitoring and diet analysis in UK children

Praosiri Charusalaipong, Ruth Slater, Margaret-Jane Gordon, Silvia W. Gratz

University of Aberdeen

Multiple mycotoxin exposure during pregnancy and its association with adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh

Nicholas Nana Adjei Kyei^1,2,3, Jillian Waid^3,4, Nurshad Ali⁵, Benedikt Cramer⁶, Hans-Ulrich Humpf⁶, Sabine Gabrysch^1,2,3

¹Institute of Public Health, Charité – Universitätsmedizin Berlin, Germany; ²Heidelberg Institute of Global Health, Heidelberg University, Germany; ³Research Department 2, Potsdam Institute for Climate Impact Research (PIK), Germany; ⁴Helen Keller International–Bangladesh Country Office, Dhaka, Bangladesh; ⁵Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh; ⁶Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Germany

Longitudinal biomonitoring of mycotoxins in pregnant women from the Yale Pregnancy Outcome Prediction Study

Magdalena Krausova¹, Kolawole I. Ayeni¹, Yasmin Borutzki¹, Yunyun Gu¹, Caroline Johnson², Benedikt Warth¹

¹University of Vienna, Austria; ²Yale School of Public Health,United States of America

Online solid phase extraction coupled to LC-MS/MS enables sensitive high-throughput analysis of mycotoxin biomarkers in urine

Michael Kuhn, Benedikt Cramer, Hans-Ulrich Humpf

Institute of Food Chemistry, University of Münster, Germany

Human biomonitoring of multiple mycotoxins in the Flemish child and adult population: results of the FLEXiGUT project

Elias Maris^1,2, Roger Pero-Gascon¹, Marthe De Boevre¹, Jeroen Raes², Tim Nawrot³, Adrian Covaci⁴, Lynn Vanhaecke⁵, Sarah De Saeger¹

¹Centre of Excellence in Mycotoxicology and Public Health, University of Ghent, 9000 Ghent, Belgium; ²Laboratory of Molecular Bacteriology, VIB-KU Leuven, 3000 Leuven, Belgium; ³Centre for Environmental Sciences, Hasselt University, 3590 Diepenbeek, Belgium; ⁴Toxicological Centre, University of Antwerp, 2610 Wilrijk, Belgium; ⁵Laboratory of Integrative Metabolomics, University of Ghent, 9820 Merelbeke, Belgium

Sorption and stability of Fusarium mycotoxins in agricultural soils

Sven Korz, Katherine Munoz

Institute for Environmental Sciences, RPTU (University of Kaiserslautern-Landau), Landau, Germany

Navigating complexity: modelling mycotoxin to face climate change

Marco Camardo Leggieri, Paola Battilani

Università Cattolica del Sacro Cuore, Italy

The impact of weather and climatic change to mycotoxins in 15 years

Alexander Platzer, Younos Cherkaoui, Gerd Schatzmayr

dsm-firmenich, Animal Nutrition and Health R&D Centers, Switzerland and Austria

Neurological disease with hazardous indoor macrocyclic trichothecenes exposure

Irene Hanchett Grant¹, Noem Olivo², Jake B. Geller³, Herman Sabath⁴, Harriet Ammann⁵

¹Integrative Medicine Group, United States of America; ²CRO Services (Independent CRO), USA; ³Geller Consulting Associates, President, USA; ⁴Indoor Environmental Diagnostics & Solutions, LLC. USA; ⁵NA

Fungal bioaerosol in historic places - An invisible cateran

Elena Piecková¹, Renáta Lehotská¹, Soňa Wimmerová²

¹Faculty of Medicine; ²Faculty of Public Health, Slovak Medical University, Bratislava, Slovak Republic

The link between sporulation and satratoxin production in Stachybotrys chartarum

Sebastian Ulrich¹, Christiane Baschien², Robert Kosicki³, Magdalena Twarużek³, Reinhard K. Straubinger¹, Frank Ebel¹

¹Chair of Bacteriology and Mycology, Department of Veterinary Sciences, Faculty of Veterinary Medicine, Institute for Infectious Diseases and Zoonosis, LMU Munich, Sonnenstr. 24, 85764 Oberschleißheim, Germany; ²Leibniz--Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstr. 7B, 38124 Braunschweig, Germany; ³Kazimierz Wielki University, Faculty of Biological Sciences, Department of Physiology and Toxicology, Chodkiewicza 30, 85–064 Bydgoszcz, Poland

The mycotoxin food contaminant alternariol impedes oxaliplatin-induced immunostimulation

Sonja Hager¹, Judith Gufler¹, Petra Heffeter², Doris Marko¹

¹Department of Food Chemistry and Toxicology, Faculty of Chemistry, University Vienna, Vienna, Austria; ²Center for Cancer Research, Medical University of Vienna, Vienna, Austria

Digging into the mechanics of alternariol toxicity – spotlighting kinases inhibition at a “kinome” level

Lorenzo Pedroni¹, Florinda Perugino^1,2, Gianni Galaverna¹, Doris Marko³, Chiara Dall'Asta¹, Luca Dellafiora¹

¹Department of Food and Drug, University of Parma, Parma, Italy; ²Department of Biology, University of Naples Federico II, Naples, Italy; ³Department of Food Chemistry and Toxicology, University of Vienna, Vienna, Austria

A new level to rise the current understanding of ochratoxin A toxicity from a molecular standpoint: an in silico journey

Lorenzo Pedroni¹, Florinda Perugino^1,2, Gianni Galaverna¹, Chiara Dall'Asta¹, Luca Dellafiora¹

¹Department of Food and Drug, University of Parma, Parma, Italy; ²Department of Biology, University of Naples Federico II, Naples, Italy

Determination of TK parameters and iTTC of tenuazonic acid through a human toxicokinetic trial and PopTK modelling

Lia Visintin¹, En-Hsuan Lu², Hsing-Chieh Lin², Truong Nguyen¹, Weihsueh Chiu², Sarah De Saeger^1,3, Marthe De Boevre¹

¹Centre of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium; ²Interdisciplinary Faculty of Toxicology, Texas A&M University, College Station, USA.; ³Department of Biotechnology and Food Technology, University of Johannesburg, Gauteng, South Africa

Dietary exposure: the mycotoxin deoxynivalenol increases the genotoxicity of haem iron

Delphine Payros^1,2, Marion Garofalo¹, Margaux Lalaurie¹, Marie Penary², Florence Mompart¹, Sylvie Puel¹, Nathalie Naud¹, Florence Blas-Y-Estrada¹, Mikaël Albin¹, Aurélia Astruc¹, Julien Vignard¹, Philippe Pinton¹, Gladys Mirey¹, Elodie Rousseau-Bacquié¹, Fabrice Pierre¹, Françoise Guéraud¹, Isabelle P. Oswald¹

¹INRAE, UMR1331, Toxalim, Research Centre in Food Toxicology, Toulouse, France; ²IRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France