Validating the e-mail address is 
optional in ConfTool Pro. Users without validated e-mail addresses can also use the system, submit papers, do reviews and register for participation. So validation is 
not required to use the system.
Users without validated e-mail addresses will also receive confirmation e-mails and messages if you use the bulk e-mail function.
However, validating their e-mail address gives users 
read access to the submissions where they are listed as 
Co-Authors with their e-mail address. 
Furthermore, the co-authored papers also get listed on the 
confirmation for participation and the invitation letter.
For further information on how to validate the e-mail address, please take a look here:
Co-author: How can I validate my e-mail address to access additional information in ConfTool?